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Anti human EpCAM monoclonal antibody


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EpCAM

EpCAM (CD326) is a transmembrane glycoprotein involving cell adhesion, cell growth and tumor progression. Its overexpression is a popular trait of almost all epithelial cancer so that EpCAM is considered as a marker for diagnostics and prevention against epithelial cancer.
To date, it has been found that the number of circulating tumor cells (CTC) from solid tumor (epithelial origin) in blood correlate with prognosis of spread breast cancer, prostatic cancer and colon cancer. Therefore EpCAM is used for CTC measurement in blood as it express on CTC.

 

KIJY

Features

 The extracellular part of EpCAM which is transmembrane glycoprotein consist of 3 parts, an N-terminal EGF domain, a TY-like domain, and an uncharacterized cysteine-poor (CP) region. Most commercially available monoclonal antibodies to EpCAM bind to the small EGF domain. However, this monoclonal antibody (clone: KIJY2) to EpCAM binds to the CP region and is generated by Masashi Takao, Institute of Development, Aging and Cancer, Tohoku University. (Reference 1,2)

 

 ・Clone:KIJY2(recognize CP domain)

 

  Other antibodies to EpCAM, EGF domain

 ・Clone:KIJY1N (recognize EGF domain)

 ・Clone:KIJY3N (recognize EGF domain)

 
References
・1 MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY Volume 32, Number 2, 2013 Masashi Takao, Yutaka Nagai, and Tokiji Torii
・2 JP2014-105159A 
 
 KIJY flyer
 

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